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Metabolism

COX17 acetylation via MOF–KANSL complex promotes mitochondrial integrity and function

COX17

Metabolic support by macrophages sustains colonic epithelial homeostasis

macrophage
polyamines
spermine
mTORC1

GIPR/GLP-1R dual agonist therapies for diabetes and weight loss—chemistry, physiology, and clinical applications

GIPR
GLP-1R
diabetes

Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma

metabolic dysfunction
Steatohepatitis

A big STEP for treatment of heart failure with preserved ejection fraction

Autophagy
Heart

A Metabolic Handbook for the COVID-19 Pandemic

Metabolism
covid-19
sars

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

inflammaging
T cells
metformin
Autophagy

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury

Efferocytosis
arginine
ornithine
efferocytosis

High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy

cardiovascular
macrophage
mTOR
mitophagy

Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function

mitochondria
Lipids
treg

Pagination

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Autophagy, Inflammation, & Metabolism Center of Biomedical Research Excellence

The AIM Center is funded by NIH grant P20GM121176, and it endows the state of New Mexico and the surrounding region with a state-of-the-art biomedical center and an intellectual and technological hub for cutting-edge research. On a larger scale, the AIM Center promises to be a nationally important center for the advancement of research on autophagy.

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