March 13th, 2026
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U&A is a gold open-access, peer-reviewed journal that aims to provide a premier forum for a broad coverage of research in the field of modifications of proteins and membranes. The primary focus is on...
The mitochondrial unfolded protein response (UPRmt), a mitochondria-to-nucleus retrograde pathway, plays an important role in maintaining mitochondrial function under stress condition. However, its...
The mitochondrial sodium-calcium exchanger, NCLX, is a critical route of mCa2+ efflux in excitable tissues, such as the heart and brain, and animal models support NCLX as a promising therapeutic...
This book covers the emerging field of membrane atg8ylation in 19 chapters contributed by the world’s best experts.
Patients with type 2 diabetes (T2D) are more susceptible to severe respiratory viral infections, but the underlying mechanisms remain elusive. The team led by Dr. Guang Sheng Ling at the University of...
Despite the recognition of the implication of mitochondria DNA (mtDNA) in various diseases, the mechanisms regulating mtDNA copy number and expression are not completely understood. Dr. Zuryn's group...
While heterogeneity is a key feature of cancer, understanding metabolic heterogeneity at the single-cell level remains a challenge. Here we present 13C-SpaceM, a method for spatial single-cell isotope...
Glucose, the primary cellular energy source, is metabolized through glycolysis initiated by the rate-limiting enzyme hexokinase (HK). In energy-demanding tissues like the brain, HK1 is the dominant...
Our body tends to produce excess FAs to ensure that the FA availability is not limiting. The surplus FAs are actively re-esterified into glycerides, initiating a cycle of breakdown and resynthesis of...