Join us at the annual AIM Center Symposium on Friday, February 22, 2019 for a day of plenary talks and workshops by leading autophagy scientists from around the world.
The symposia, hosted by Drs. Vojo Deretic (AIM Center Director), Leon Murphy (Casma Therapeutics, USA), and Li Yu (Tsinghua University, China), will take place in the Domenici Center Auditorium at the Health Sciences Center, University of New Mexico. This event will follow the 2019 Keystone autophagy meeting in Santa Fe. To register (free) for the AIM satellite symposium, click here, otherwise, click below for the full list of speakers and additional information!
"We introduce for the first time a specific role for MITF in autophagy control that involves upregulation of MIR211. We show that, under stress conditions including starvation and MTOR inhibition, a MITF-MIR211 axis constitutes a novel feed-forward loop that controls autophagic activity in cells"
Read more from the AIM Center's International Council Affiliate member, Dr. Devrim Gozuacik and his group!
Beige adipocytes are present in white adipose tissue (WAT) and have thermogenic capacity to orchestrate substantial energy metabolism and counteract obesity. However, adipocyte-derived signals that act on progenitor cells to control beige adipogenesis remain poorly defined. Here, we show that adipose-specific depletion of Raptor, a key component of mTORC1, promoted beige adipogenesis through prostaglandins (PGs) synthesized by cyclooxygenase-2 (COX-2)...
"Our studies conducted in late 1990s reported on the phosphatidylinositol 3-phosphate (PI3P) mechanism of the Mycobacterium tuberculosis (Mtb) phagosome maturation block. At that time we wondered whether there was any naturally occurring cellular process that could be used to advance Mtb phagosomal maturation..." continue reading.
RAC3 is a member of the p160 family of steroid receptor coactivators and it is highly expressed in several human cancers, contributing to enhanced cell proliferation and cellular transformation...