News

05.26.2023

The G protein-coupled oestrogen receptor GPER in health and disease: an update

Oestrogens and their receptors contribute broadly to physiology and diseases. In premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic and neurological diseases and are involved in hormone-sensitive cancers such as breast cancer. Oestrogens and oestrogen mimetics mediate their effects via the cytosolic and nuclear receptors oestrogen receptor-α (ERα) and oestrogen receptor-β (ERβ) and membrane subpopulations as well as the 7-transmembrane G protein-coupled...

04.17.2023

ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion

ATG5 is a part of the E3 ligase directing lipidation of ATG8 proteins, a process central to membrane atg8ylation and canonical autophagy. Loss of Atg5 in myeloid cells causes early mortality in murine models of tuberculosis. This in vivo phenotype is specific to ATG5. Here, we show using human cell lines that absence of ATG5, but not of other ATGs directing canonical autophagy, promotes lysosomal exocytosis and secretion of extracellular vesicles and, in murine Atg5fl/fl LysM-Cre neutrophils...

Expression of Interest

At this time, we are accepting an Expression of Interest (EOI) by prospective candidates. The Autophagy Inflammation and Metabolism Center (AIM) is planning to conduct periodic searches for competitive mentored PI (mPI) positions to be supported by the AIM P20 NIH award. 

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Latest

05.26.2023
Autophagy

Oestrogens and their receptors contribute broadly to physiology and diseases. In premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic and neurological diseases and are...

05.26.2023
Event
Event Date: 05.30.2023

The AIM Center will be having a special Tuesday AIM Session this coming Tuesday, May 30, 2023 at 3pm (MST), featuring AIM Statistics Workshop, by Dr. Yiliang Zhu!

Metabolism Corner

07.09.2020
Metabolism

For COVID-19 and all other infectious diseases, metabolic processes are intimately connected to the mechanisms of disease pathogenesis and the resulting pathology and pathophysiology, as well as the host defence response to the infection. This article discusses why preexisting metabolic...

07.09.2020
Metabolism

Metformin improves CD4+ T cell autophagy and mitochondrial respiration, ameliorating a newly defined inflammaging profile that echoes inflammation in diabetes. Metformin-sensitive defects in immune cell autophagy accompany natural aging in people, shift mitochondrial bioenergetics, and fuel a...

At this time, we are accepting an Expression of Interest (EOI) by prospective candidates. The Autophagy Inflammation and Metabolism Center (AIM) is planning to conduct periodic searches for...