News
A new AIM Center publication by Dr. Suresh Kumar of Dr. Vojo Deretic's lab! Dr. Kumar shows how Syntaxin 17 hs been implicated in autophagosome-lysosome fusion.
Vojo Deretic Ph.D. gives a seminar at the Institute of Molecular and Cell Biology, Singapore on Autophagy and membrane trafficking.
A review by Dr. Eliseo Castillo and colleagues. Dr. Castillo is a recipient of a pilot award from the AIM Center and studies how autophagy affects T cell responses.
International Council of Affiliate Members
The AIM Center's International Council of Affiliate Members map.
Vibrant Campus Initiative
The AIM Center is excited to reveal a new program in the works - The Vibrant Campus Initiative Program (VIP), which is currently being finalized. Follow us in Twitter to stay up-to-date!
Latest
Mutations in PTEN-induced kinase 1 (PINK1) can cause recessive early-onset Parkinson’s disease (PD). Import arrest results in PINK1 kinase activation specifically on damaged mitochondria, triggering Parkin-mediated mitophagy. Here, we show that PINK1 import is less dependent on Tim23 than on mitochondrial membrane potential (ΔΨm)...
Viral infection triggers host defenses through pattern-recognition receptor-mediated cytokine production, inflammasome activation, and apoptosis of the infected cells. Inflammasome-activated caspases are known to cleave cyclic GMP-AMP synthase (cGAS). Here, we found that apoptotic caspases are critically involved in regulating both DNA and RNA virus-triggered host defenses, in which activated caspase-3 cleaved cGAS, MAVS, and IRF3 to prevent cytokine overproduction...
The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy-related (ATG) genes...