News
AIM center researchers, Drs. Meilian Liu and Xuexian Yang et all; have just published their findings in Nature - Scientific Reports on the "... previously unappreciated insight that obesity-associated hyperleptinemia contributes to enhanced pro-allergic lymphocyte responses through induction of XBP1s, leading to exacerbation of allergic asthma."
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A brief snippet - "Gal8 inhibits mTOR activity through its Ragulator-Rag signaling machinery, whereas galectin-9 activates AMPK in response to lysosomal injury. Both systems converge upon downstream effectors including autophagy and defense against Mycobacterium tuberculosis. Thus, a novel galectin-based signal-transduction system, termed here GALTOR, intersects with the known regulators of mTOR on the lysosome and controls them in response to lysosomal damage."
Latest
A review by Kroemer, Galluzzi and colleagues on immune control of cancer a part of a compendium of reviews on "autophagy and inflammation" see other articles in 2018
Autophagy, inflammation and cancer - covered by Debnath and Monkkonen for the special issue of "autophagy and inflammation"
Monique Copeland and Paul Tillberg Explain Expansion Microscopy...
The immune system protects the body by responding to invading organisms. But how is an attack on useful resident microbes prevented? A pathway has now been identified that allows immune cells to sense and respond to beneficial bacteria.