Graphical abstract of Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation
posted 03.15.2019 ○ Research
Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation

A new AIM Center publication by Dr. Suresh Kumar of Dr. Vojo Deretic's lab! Dr. Kumar shows how Syntaxin 17 hs been implicated in autophagosome-lysosome fusion.

Vojo Deretic Ph.D. Lecture - Institute of Molecular and Cell Biology
posted 03.15.2019 ○ Seminar
Seminar by Vojo Deretic Ph.D. at IMCB in Singapore

Vojo Deretic Ph.D. gives a seminar at the Institute of Molecular and Cell Biology, Singapore on Autophagy and membrane trafficking.

Schematic of the autophagic process
posted 01.25.2019 ○ Research
Modulating T Cell Responses via Autophagy: The Intrinsic Influence Controlling the Function of Both Antigen-Presenting Cells and T Cells

A review by Dr. Eliseo Castillo and colleagues. Dr. Castillo is a recipient of a pilot award from the AIM Center and studies how autophagy affects T cell responses.


03.15.2019 ○ News

Mutations in PTEN-induced kinase 1 (PINK1) can cause recessive early-onset Parkinson’s disease (PD). Import arrest results in PINK1 kinase activation specifically on damaged mitochondria, triggering Parkin-mediated mitophagy. Here, we show that PINK1 import is less dependent on Tim23 than on mitochondrial membrane potential (ΔΨm)...

03.10.2019 ○ News

Viral infection triggers host defenses through pattern-recognition receptor-mediated cytokine production, inflammasome activation, and apoptosis of the infected cells. Inflammasome-activated caspases are known to cleave cyclic GMP-AMP synthase (cGAS). Here, we found that apoptotic caspases are critically involved in regulating both DNA and RNA virus-triggered host defenses, in which activated caspase-3 cleaved cGAS, MAVS, and IRF3 to prevent cytokine overproduction...

01.23.2019 ○ Cell

The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy-related (ATG) genes...

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