Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function

Fatty acid binding protein 5 (FABP5) is gatekeeper of mitochondrial integrity that modulates Treg function via a mechanism involving mtDNA release, cGAS-STING-dependent type I IFN signaling and heightened production of the regulatory cytokine IL-10.

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