Metabolism | Autophagy, Inflammation and Metabolism Center of Biomedical Research Excellence

Metabolism

Graphical Abstract

Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity

immunometabolism

Graphical Abstract

STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth

Multidimensional mitophagy screen reveals that ANT is required for mitophagy

The ADP/ATP Translocase Drives Mitophagy Independent of Nucleotide Exchange

nucleotide exchange

Lipid Signaling Drives Proteolytic Rewiring of Mitochondria by YME1L

Fatty Acid Metabolites Combine with Reduced β Oxidation

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

fatty acid oxidation

immunometabolism

Conserved functions in vertebrates

Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism

regulatory T cells

tissue homeostasis

CD8 T Cell glycolytic metabolism

Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells

Graphical Abstract

Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer

cancer stem cells

prostate cancer

mitochondrial dynamics

mitochondrial fission

UA phase 1 study

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

Graphical abstract CD8+ T cell

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

immune checkpoints

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