Metformin improves CD4+ T cell autophagy and mitochondrial respiration, ameliorating a newly defined inflammaging profile that echoes inflammation in diabetes. Metformin-sensitive defects in immune...
News
Presentation by: Eric Prossnitz, Phd |
In addition to the International Council of Affiliate Members (ICAM), the AIM Center announces formation of medical specialties-based sections within its newly formed National Council of Affiliate...
(Special Covid-19/TAIMS)
Bryce C. Chackerian, PhD
“Vaccine strategies for SARS-CoV-2”
David S. Peabody, PhD
“Making a SARS-CoV-2 vaccine on an RNA phage-derived platform”
Published:
| FULLTEXT 11.06.2019
The tripartite motif (TRIM) proteins constitute a family of ubiquitin E3 ligases involved in a multitude of cellular processes, including protein homeostasis and autophagy. TRIM32 is characterized by six protein-protein interaction domains termed NHL, various point mutations in which are associated...
Published:
| FULLTEXT 11.11.2019
Estrogen exerts extensive and diverse effects throughout the body of women. In addition to the classical nuclear estrogen receptors (ERα and ERβ), the G protein-coupled estrogen receptor GPER is an important mediator of estrogen action. Existing ER-targeted therapeutic agents act as GPER agonists...
Published:
| FULLTEXT 12.10.2019
Endomembrane damage elicits homeostatic responses including ESCRT-dependent membrane repair and autophagic removal of damaged organelles. Previous studies have suggested that these systems may act separately. Here, we show that galectin-3 (Gal3), a β-galactoside-binding cytosolic lectin, unifies and...
Published:
| FULLTEXT 12.17.2019
Dysregulation of macroautophagy/autophagy is implicated in obesity and insulin resistance. However, it remains poorly defined how autophagy regulates adipocyte development. Using adipose-specific knockout (KO), KO and double-KO mice, we show that inhibiting MTORC1 by RPTOR deficiency led to...
A BioRxiv preprint in the BioRxiv COVID-19 collection: a study from the AIM center indicating that azithromycin and ciprofloxacin have effects similar to chloroquine in human respiratory epithelial...
Drs. Alison Kell and Suresh Kumar have been awarded the first two CoV2 pilot award by the AIM Center. As the world continues to rally against Covid-19, the AIM center hopes to be at the forefront of...