Autophagy and inflammation: A special review issue.

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Journal Article

a Department of Molecular Genetics and Microbiology , University of New Mexico Health Sciences Center , Albuquerque , NM USA.,b Autophagy Inflammation and Metabolism Center of Biomedical Research Excellence , University of New Mexico Health Sciences Center , Albuquerque , NM USA.
c Life Sciences Institute, University of Michigan , Ann Arbor , MI USA.


Macroautophagy/autophagy is a fundamental intracellular homeostatic process that is of interest both for its basic biology and for its effect on human physiology in a wide spectrum of conditions and diseases. Autophagy was first appreciated primarily as a metabolic and cytoplasmic quality control process, but in the past decade its role in immunity has been steadily growing. The connections between these aspects beckon explorations of the network and connections that exist between metabolism, quality control, and inflammation and immunity processes, which are so key to many human diseases including neurodegeneration, obesity and diabetes, chronic inflammatory conditions, cancer, infection, and aging. The purpose of this issue is to stimulate further the burgeoning studies of the intersections between autophagy and inflammation, and the inevitable overlaps with metabolic and quality control functions of autophagy.