For these awards, proposals should incorporate a basic science approach and should address the topic of autophagy, inflammation, metabolism, cell biology and other areas in the context of a disease state that also meets the requirements of the Bio-MT Center. Applications are welcome from high-risk-/high-reward proposals that might prove innovative (and even disruptive vis-à-vis established paradigms) of high impact. A path for continuation and utilization of resources at the two institutions or nationally available resources accessible to users should be articulated.