Beige adipocytes are present in white adipose tissue (WAT) and have thermogenic capacity to orchestrate substantial energy metabolism and counteract obesity. However, adipocyte-derived signals that act on progenitor cells to control beige adipogenesis remain poorly defined. Here, we show that...
Allergic asthma, a chronic respiratory disease, is a leading worldwide health problem, which inflames and constricts the airways, leading to breathing difficulty. Many studies have focused on the pathogenesis contributed by the adaptive immune system, including CD4 T lymphocytes in delayed type...
The autophagy pathway known also as macroautophagy (herein referred to as autophagy) is characterized by the formation of double-membrane organelles that capture cytosolic material. Based on pathway termination alternatives, autophagy has been divided into degradative and secretory. During...
The Ser/Thr protein kinase mTOR controls metabolic pathways, including the catabolic process of autophagy. Autophagy plays additional, catabolism-independent roles in homeostasis of cytoplasmic endomembranes and whole organelles. How signals from endomembrane damage are transmitted to mTOR to...
A quote from senior author Dr. Eileen White "The work is significant as it provides a mechanism by which autophagy inhibition suppresses cancer growth. Most tumors obtain nutrients from the...
"Our studies conducted in late 1990s reported on the phosphatidylinositol 3-phosphate (PI3P) mechanism of the Mycobacterium tuberculosis (Mtb) phagosome maturation block. At that time we wondered...
A new publication from Dr. Devrim Gozuacik, an affiliate member of the AIM Center International Council and his group.
Snippet - "We introduce for the first time a specific role for MITF in...
Join us at the annual AIM Center Symposium on Friday, February 22, 2019 for a day of plenary talks and workshops by leading autophagy scientists from around the world.
The symposia, hosted by Drs...
A new article from AIM Center scientists - "Beige adipocytes are present in white adipose tissue (WAT) and have thermogenic capacity to orchestrate substantial energy metabolism and counteract obesity...
The AIM Center is excited to reveal a new program in the works - The Vibrant Campus Initiative Program (VIP), which is currently being finalized. Make sure to follow us on twitter and periodically...
