News

12.06.2019

Two new publications from the AIM Center!

Two new publications have recently been published online through Cell. The first is from AIM Center co-director, Dr. Prossnitz, titled, "A Selective Ligand for Estrogen Receptor Proteins Discriminates Rapid and Genomic Signaling". You can view that here.

The second comes from Dr. Jia, from the AIM Center Director, Dr. Vojo Deretic's lab, titled "Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal". You can view that here!

Latest

12.06.2019
Research

Two new publications have recently been published online through Cell. The first is from AIM Center co-director, Dr. Prossnitz, titled, "A Selective Ligand for Estrogen Receptor Proteins Discriminates...

Metabolism Corner

12.10.2019
Metabolism

Upon TCR stimulation, pyruvate kinase M2 (PKM2) translocates into the nucleus of CD4+ cells, leading to activation of glycolysis and Th17/Th1 polarization. A small-molecule PKM2 activator TEPP-46 induces PKM2 tetramerization and blocks PKM2 nuclear translocation by which inhibits Th17 and Th1...

12.10.2019
Metabolism

Metabolic pathway fatty acid oxidation plays a critical role in the regulation of glycolysis and IFNg production in CD8+ T cells. Obesity promotes breast tumorigenesis by inhibiting CD8+ T cell glycolysis and IFNg production via adipokine leptin-dependent fatty acid oxidation.