For COVID-19 and all other infectious diseases, metabolic processes are intimately connected to the mechanisms of disease pathogenesis and the resulting pathology and pathophysiology, as well as the...
News
Metformin improves CD4+ T cell autophagy and mitochondrial respiration, ameliorating a newly defined inflammaging profile that echoes inflammation in diabetes. Metformin-sensitive defects in immune...
Presentation by: Eric Prossnitz, Phd |
In addition to the International Council of Affiliate Members (ICAM), the AIM Center announces formation of medical specialties-based sections within its newly formed National Council of Affiliate...
(Special Covid-19/TAIMS)
Bryce C. Chackerian, PhD
“Vaccine strategies for SARS-CoV-2”
David S. Peabody, PhD
“Making a SARS-CoV-2 vaccine on an RNA phage-derived platform”
Published:
| FULLTEXT 11.06.2019
The tripartite motif (TRIM) proteins constitute a family of ubiquitin E3 ligases involved in a multitude of cellular processes, including protein homeostasis and autophagy. TRIM32 is characterized by six protein-protein interaction domains termed NHL, various point mutations in which are associated...
Published:
| FULLTEXT 11.11.2019
Estrogen exerts extensive and diverse effects throughout the body of women. In addition to the classical nuclear estrogen receptors (ERα and ERβ), the G protein-coupled estrogen receptor GPER is an important mediator of estrogen action. Existing ER-targeted therapeutic agents act as GPER agonists...
Published:
| FULLTEXT 12.10.2019
Endomembrane damage elicits homeostatic responses including ESCRT-dependent membrane repair and autophagic removal of damaged organelles. Previous studies have suggested that these systems may act separately. Here, we show that galectin-3 (Gal3), a β-galactoside-binding cytosolic lectin, unifies and...
Published:
| FULLTEXT 12.17.2019
Dysregulation of macroautophagy/autophagy is implicated in obesity and insulin resistance. However, it remains poorly defined how autophagy regulates adipocyte development. Using adipose-specific knockout (KO), KO and double-KO mice, we show that inhibiting MTORC1 by RPTOR deficiency led to...
A BioRxiv preprint in the BioRxiv COVID-19 collection: a study from the AIM center indicating that azithromycin and ciprofloxacin have effects similar to chloroquine in human respiratory epithelial...