Liver macrophages regulate systemic metabolism through non-inflammatory factors

Liver macrophages regulate systemic metabolism through non-inflammatory factors
Liver macrophages regulate systemic metabolism through non-inflammatory factors

FULLTEXT: Nature

Abstract

Liver macrophages (LMs) have been proposed to contribute to metabolic disease through secretion of inflammatory cytokines. However, anti-inflammatory drugs lead to only modest improvements in systemic metabolism. Here we show that LMs do not undergo a proinflammatory phenotypic switch in obesity-induced insulin resistance in flies, mice and humans.

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