Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer

Graphical Abstract
Graphical Abstract

Abstract

BRD4, one of Bromodomain and extra-terminal domain (BET) proteins that bind to acetylated histones and transcription factors (TFs) and control cell-type-specific transcriptional programs, promotes mitochondrial fission and thereby enables asymmetric division and prostate cancer stem cell self-renewal.

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